Technological knowledge


Tips for scalp care: Say goodbye to seborrheic dermatitis

Tips for scalp care: Say goodbye to seborrheic dermatitis

Taiwan is a subtropical climate type of island. It is usually hot and humid during summer, causing an increase of sweat on the scalp and other scalp problems. There is still no exact cause of seborrheic dermatitis. It occurs most often in infants younger than three months old and in adults ages 30 to 60 and is more common in men than in women. Seborrheic dermatitis is prone to occur in oily areas of the body, such as the face, sides of the nose, eyebrows, ears, eyelids and chest. Sometimes it even occurs under the armpits and vulva (external female genitals). For the scalp, mild symptoms usually manifest as dandruff. In severe cases, in addition to a large amount of dandruff, the scalp is often accompanied by inflammation and redness.

Causes of seborrheic dermatitis

So far, the exact cause of seborrheic dermatitis is not clear, but it is indeed an inflammatory reaction of the skin. It is generally believed that seborrheic dermatitis is related to fungal infections. Scurf pityrosporion ovale is a type of Malassezia globosa. In 2007, Scientists from P&G Beauty announced that they successfully sequenced the complete genome for Malassezia globosa (M. globosa), and published the results in the internationally renowned journal National Academy of Sciences (PNAS November 20, 2007 104 (47) 18730-18735).

Malassezia globosa was found to have 4285 genes, about 1/300th the size of the human genome, and is a common symbiotic bacteria on the human scalp. According to statistics, the average human can host to up to 10 million M. globosa and they usually rely on the long carbon chain fatty acids secreted by the scalp sebaceous glands as nutrients. When the M. globosa of the human scalp multiply too fast, the metabolism of the scalp epidermal cells will be disturbed, and itching or dandruff will accompany it. In severe cases, it will cause scalp inflammation and seborrheic dermatitis.

Seborrheic dermatitis is also closely related to oxidative stress ( Studies have found that Malassezia globosa can trigger immune cells to release free radicals, which are reactive oxygen species (ROS) to eliminate these foreign pathogens, but too much ROS can increase the oxidative pressure of cells and induce scalp inflammation. On the other hand, some studies have shown that the Malassezia globosa itself can also generate ROS to stimulate the scalp and cause scalp inflammation ( 
Nowadays the mental health crisis is in full swing and worryingly. Irregular dietary habits, over work, staying up late and other external environmental factors could cause a sudden increase in the body's oxidative pressure and seborrheic dermatitis as well.
Take care of your scalp!Say goodbye to seborrheic dermatitis
We just briefly introduced several possible causes of seborrheic dermatitis. Before starting the preventive care, if the scalp has itchy or inflammatory reactions, it is recommended to seek the assistance and diagnosis of a professional doctor to make sure the possible cause.
The preventive care of seborrheic dermatitis actually has to consider multiple aspects at the same time. After all, the scalp is part of the organs of the body. To provide a healthy environment for the scalp both inside and outside is the most important thing to do in the beginning 
The following summarizes several common preventive care tips for seborrheic dermatitis:
1. Clean the scalp moderately and choose the right shampoo for seborrheic dermatitis treatment:
Moderate scalp cleansing can not only wash away excess sweat and grease to keep the scalp dry, but also effectively reduce the proliferation of Malassezia globosa and eliminate many factors that induce seborrheic dermatitis. On the other hand, there are also many medicated shampoos currently on the market. The common ingredients include Ketoconazole, Climbazole, Zinc pyrithione, piroctone olamine, etc., which are a great way toprevent seborrheic dermatitis. 
2. Keep a healthy life habit. Reduce scalp oxidative stress and ROS:
Scalp seborrheic dermatitis is also related to life habit. Avoid staying up late and irregular dietary habits. Exercising more and getting more sun will help the body secrete melatonin at night to help you fall asleep. The strong light interference from the mobile phone before going to bed will also disrupt the body's biological clock. The strong light of the mobile phone will affect the secretion of human melatonin. Not using mobile phone before going to bed is one of the good ways to reduce scalp oxidative stress.
Keep a balance of Scalp oxidative stress is the key
Human aging or external factors such as stress, over work and irregular dietary habits will cause excessive oxidative stress in the human body, which may even exceed the range that the body can afford, leading to a series of inflammatory reactions. For the scalp, it may lead to seborrheic dermatitis in the end.
Nowadays, the shampoos developed for seborrheic dermatitis contain steroids or antibacterial ingredients as much as the above-mentioned ingredients. Therefore, many consumers will choose some shampoos that are plant extracts or contain natural ingredients. However, Such products usually lack objective scientific evidence. In addition, as mentioned earlier, seborrheic dermatitis is closely related to oxidative stress. It may be a good point to look at the topic of preventive care of seborrheic dermatitis from the perspective of reducing the body's oxidative stress.

When it comes to oxidative stress, we have to mention our body’s antioxidant system. In the past, the body has developed a unique anti-oxidant system in order to combat the damage caused by the oxidative stress. At the top of the pyramid is a highly active enzyme called SOD (Superoxide Dismutase). When the body's oxidative pressure increases, the amount of ROS increases. At this time, superoxide dismutase will convert ROS into H2O2 and O2 through a disproportionation reaction to maintain the balance of the body's oxidative pressure.

The world’s first biomimetic SOD stable at room temperature

Superoxide dismutase(SOD) is a kind of super high activity enzyme, as long as it exposes to the air, it will oxidize immediately. For more than half a century, maintaining the high activity of superoxide dismutase in room temperature has been a goal pursued by scientists. After years of development, Ti-Unic Biotech has finally successfully developed the world's first biomimetic superoxide dismutase that can be stable in room temperature. This technology has obtained eight patents in seven countries since 2014. In 2018, we commissioned the Institute of Biomedicine of Industrial Technology Research Institute to conduct related efficacy verification. It was found that TUN-828® can effectively remove free radicals in cells within 16 hours, and effectively inhibit the degranulation of mast cells and the inflammatory factors secreted by macrophages.

Recently, a series of human clinical trials have been launched in cooperation with the medical school, and it has been found that TUN-828® has a positive effect on improving the health of the scalp.

We are proud to say that TUN-828® is the world’s first biomimetic superoxide dismutase with relatively sufficient scientific evidence and can be applied to the scalp. If you are interested in our TUN-828®, please contact us to learn more! 



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